Dementia Disease Treatment with Stem Cells

With stem cell therapy, the progression of DEMENTIA disease can be slowed down and regressed. The success rate of the treatment is proportional to the patient's age, the duration of the disease and the patient's condition.

The treatment of DEMENTIA disease with stem cells is recognized as a new method that scientists are working on.
Stem cells have the ability to turn into brain cells when they touch damaged brain cells. Stem cells are therefore used in the treatment of DEMENTIA.
The number of cells to be administered is determined according to the age and weight of the patient. The treatment can be performed in 3 sessions 45 days apart or in 3 consecutive days.
The size of the administered stem cells is small enough to pass through the brain cells. Therefore, the success rate of the treatment increases significantly in early diagnosis. Previous studies reported a very high percentage of positive results with stem cell therapy.

What is Dementia?

Dementia, which is popularly known as mental decline is a state of inadequacy in a person's mental functions such as memory and language abilities, abstract thinking and judgment due to the illness.

Dementia is the most common cause of disability in people over 60 years of age and the incidence of this disease increases as the life span increases. While the risk of dementia is 5% at age 65, the risk doubles every 5 years and reaches 40-50% over 85 years of age.

It is a known fact that forgetfulness is the most common complaint in old age, and it is often considered as the natural result of aging, but forgetfulness in the elderly may have many medical reasons. Dementia, which is the most common cause of mental decline, is one of the important causes of forgetfulness in the elderly.

It is known that there are 200 different types of diseases that cause dementia since they weaken the brain.

What are the Symptoms of Dementia?

The initial symptoms of the disease;

Memory problems, forgetfulness and memory loss
Difficulties in doing routine behaviors
Having trouble finding the right words
Sudden mood swings
Apathy - Indifference, lack of morale and insecurity
Difficulties in carrying out and completing normal daily tasks
Confusion, inability to remember people's faces and names
Difficulty in following stories and events
Unsuccessful sense of direction, getting lost all the time
Repetitive behavior, asking the same questions again and again or telling the same things by repeating them
Incompatibility with change, forgetting why they do something and panicking
Regression in mental skills
Difficulty finding words and remembering the names of objects
Difficulty in calculating and dealing with numbers

Causes of Dementia

Cognitive losses, such as forgetfulness, may occur due to advanced age. This age-related condition occurs as a result of nerve cell damage caused in the brain due to advanced age and is not dementia. Thyroid function disorders such as hypothyroidism, anemia, vitamin B12 and folic acid deficiencies and some other medical conditions are among the causes of forgetfulness in the elderly.

The complaint of forgetfulness in the elderly should be taken seriously. The cause of forgetfulness should be determined upon carrying out various evaluations. Since some problems and diseases that cause dementia can be treated, the progression of the disease can be slowed down. For example, problems such as metabolic disorders, depression, drug side effects, and wrong drug use can be prevented. Therefore, early detection of the problem causing dementia is very important.

Dementia Disease Treatment

The success of dementia treatment depends on the source and severity of the disease causing the problem. Informing the patient and the relatives in detail, providing the support they need is very important for healing and also for the quality of life. Even if there is no definite treatment, some new drugs introduced in recent years reduce the symptoms of dementia and slow the progression of the disease.

In vascular dementia, which may cause blood clotting in the brain, treatment is aimed at preventing further blood clots from forming.

Dementia patients and their relatives should be informed about the disease so that they can take precautions for future problems.

Treatment of Dementia with Stem Cells

Stem cells have the ability to turn into brain cells when they touch dying brain cells, and that being the case, they are used in the treatment of Dementia. The size of the cells given is small enough for them to penetrate into the brain tissues and therefore, the recovery rate increases significantly in early diagnosis.

The number of cells to be administered is determined according to the age and weight of the patient. Treatment is carried out using mesenchymal stem cells (derived from the patient's own adipose tissue or bone marrow). The treatment of the patient is decided according to the condition of the patient. It can be performed in 3 sessions 45 days apart or in 3 consecutive days.

The treatment protocol is precisely determined according to the patient's condition and a different protocol may be applied for each patient. The most obvious and lasting effects of the treatments were obtained in the initial stage of the disease, in which neurological and mental symptoms have appeared (in 90% of the cases). Positive results were also obtained in patients with organic brain lesions (atrophy of the frontoparietal lobes).

As a result of application of stem cells in patients with significant mental disorder, the quality of life of the patients significantly increased (general condition, sleep, appetite, etc.) as well.

This disease can be treated at our GenCell Stem Cell Treatment Center in Kiev, Ukraine.

FREQUENTLY ASKED QUESTIONS

Is Dementia a Genetic (Hereditary) disease?

Genetic factors are known to play a role in dementia. Family history of dementia is seen in 30% of the patients. This factor is more effective in patients diagnosed at a younger age (under 65 years old).

Are there any precautions to avoid Dementia?

It is known that doing sports is important to avoid Dementia. It is believed that doing physical exercise three times a week reduces the chance of dementia by 70%. Not smoking, consuming vitamin B12, taking vitamin D, reducing alcohol consumption and brain exercises are some of the measures that can be taken against Dementia.

How is dementia diagnosed?

The most important symptom of Dementia disease is the patient's forgetfulness. However, it is not right to consider all forgetfulness as Dementia. Many people experience forgetfulness in their daily lives, but continue to live without Dementia. Patients considered to have Dementia should be evaluated with neurological examinations, laboratory tests and neuropsychological tests. To people at high risk, EEG, i.e. cortical mapping, MRI and PET scans may also be recommended.

SCIENTIFIC STUDIES

Hunsberger, J. G., Rao, M., Kurtzberg, J., Bulte, J. W., Atala, A., LaFerla, F. M., ... & Doraiswamy, P. M. (2016). Accelerating stem cell trials for Alzheimer's disease. The Lancet Neurology, 15(2), 219-230.
Duncan, T., & Valenzuela, M. (2017). Alzheimer’s disease, dementia, and stem cell therapy. Stem cell research & therapy, 8(1), 111.
Sugaya, K. (2005). Possible use of autologous stem cell therapies for Alzheimer's disease. Current Alzheimer Research, 2(3), 367-376.
Ager, R. R., & LaFerla, F. M. (2016). Stem cell therapy for alzheimer's disease. Reviews in Cell Biology and Molecular Medicine.
Kang, J. M., Yeon, B. K., Cho, S. J., & Suh, Y. H. (2016). Stem cell therapy for Alzheimer’s disease: A review of recent clinical trials. Journal of Alzheimer's Disease, 54(3), 879-889.
Kim, H. J., Seo, S. W., Chang, J. W., Lee, J. I., Kim, C. H., Chin, J., ... & Kim, S. T. (2015). Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: a phase 1 clinical trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 1(2), 95-102.

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